Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
Identifieur interne : 000F57 ( Main/Exploration ); précédent : 000F56; suivant : 000F58Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
Auteurs : Margaret A. Piggott [Royaume-Uni] ; Clive G. Ballard [Royaume-Uni] ; Elise Rowan [Royaume-Uni] ; Clive Holmes [Royaume-Uni] ; Ian G. Mckeith [Royaume-Uni] ; Evelyn Jaros [Royaume-Uni] ; Robert H. Perry [Royaume-Uni] ; Elaine K. Perry [Royaume-Uni]Source :
- Synapse [ 0887-4476 ] ; 2007-11.
English descriptors
Abstract
Dementia with Lewy bodies (DLB) is a progressive dementia frequently accompanied by psychotic symptoms. Similar symptoms can occur in Alzheimer's disease (AD) to a lesser extent. The use of neuroleptic medication to treat psychosis in both diseases is of modest efficacy and can induce severe adverse reactions in DLB. Dopamine D2 receptors in the cerebral cortex are the putative target for the antipsychotic action of these drugs, but the status of these receptors in DLB is unknown. Autoradiography was used to examine the density D2 receptors in postmortem temporal cortex tissue from prospectively assessed patients with neuropathologically confirmed DLB and AD. D2 receptors were substantially (over 40%) and significantly (P < 0.001) reduced in temporal cortex in DLB, and in DLB with concomitant Alzheimer pathology, but was not significantly changed in AD. This reduction correlated with greater cognitive decline (P < 0.01), but was not significantly related to visual or auditory hallucinations or delusions. D2 receptor density was inversely correlated with cortical Lewy body pathology in the neocortex (P < 0.001). The specific loss of D2 receptors associated with Lewy body pathology, in conjunction with our previous finding of low D2 receptors in striatum in DLB, provides a possible explanation for neuroleptic intolerance. That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB. Synapse 61:903–911, 2007. © 2007 Wiley‐Liss, Inc.
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DOI: 10.1002/syn.20441
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Similar symptoms can occur in Alzheimer's disease (AD) to a lesser extent. The use of neuroleptic medication to treat psychosis in both diseases is of modest efficacy and can induce severe adverse reactions in DLB. Dopamine D2 receptors in the cerebral cortex are the putative target for the antipsychotic action of these drugs, but the status of these receptors in DLB is unknown. Autoradiography was used to examine the density D2 receptors in postmortem temporal cortex tissue from prospectively assessed patients with neuropathologically confirmed DLB and AD. D2 receptors were substantially (over 40%) and significantly (P < 0.001) reduced in temporal cortex in DLB, and in DLB with concomitant Alzheimer pathology, but was not significantly changed in AD. This reduction correlated with greater cognitive decline (P < 0.01), but was not significantly related to visual or auditory hallucinations or delusions. D2 receptor density was inversely correlated with cortical Lewy body pathology in the neocortex (P < 0.001). The specific loss of D2 receptors associated with Lewy body pathology, in conjunction with our previous finding of low D2 receptors in striatum in DLB, provides a possible explanation for neuroleptic intolerance. That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB. Synapse 61:903–911, 2007. © 2007 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Piggott, Margaret A" sort="Piggott, Margaret A" uniqKey="Piggott M" first="Margaret A." last="Piggott">Margaret A. Piggott</name></noRegion><name sortKey="Ballard, Clive G" sort="Ballard, Clive G" uniqKey="Ballard C" first="Clive G." last="Ballard">Clive G. Ballard</name><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><name sortKey="Jaros, Evelyn" sort="Jaros, Evelyn" uniqKey="Jaros E" first="Evelyn" last="Jaros">Evelyn Jaros</name><name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G." last="Mckeith">Ian G. Mckeith</name><name sortKey="Perry, Elaine K" sort="Perry, Elaine K" uniqKey="Perry E" first="Elaine K." last="Perry">Elaine K. Perry</name><name sortKey="Perry, Robert H" sort="Perry, Robert H" uniqKey="Perry R" first="Robert H." last="Perry">Robert H. Perry</name><name sortKey="Rowan, Elise" sort="Rowan, Elise" uniqKey="Rowan E" first="Elise" last="Rowan">Elise Rowan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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